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C David Allis Selected Research

Histones (Histone)

12/2021Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer.
1/2021Oncohistone mutations enhance chromatin remodeling and alter cell fates.
1/2021Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
1/2021Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.
11/2020Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
1/2020Impaired cell fate through gain-of-function mutations in a chromatin reader.
1/2020In situ chromatin interactomics using a chemical bait and trap approach.
10/2019PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor.
1/2019The expanding landscape of 'oncohistone' mutations in human cancers.
10/2017NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.
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C David Allis Research Topics

Disease

37Neoplasms (Cancer)
12/2021 - 02/2002
10Carcinogenesis
01/2021 - 09/2007
8Glioma (Gliomas)
11/2020 - 05/2013
7Leukemia
01/2020 - 03/2008
6Sarcoma (Soft Tissue Sarcoma)
01/2021 - 10/2010
4Intellectual Disability (Idiocy)
06/2015 - 12/2008
3Brain Neoplasms (Brain Tumor)
01/2019 - 11/2007
2Lymphoma (Lymphomas)
12/2021 - 01/2021
2Infections
10/2021 - 09/2020
2COVID-19
10/2021 - 09/2020
2Chondroblastoma
01/2021 - 01/2016
2Head and Neck Neoplasms (Head and Neck Cancer)
01/2021 - 01/2019
2Starvation
01/2020 - 09/2006
2Diffuse Intrinsic Pontine Glioma
01/2019 - 05/2014
2Chromosomal Instability (Chromosome Stability)
07/2015 - 08/2013
2Genomic Instability
06/2015 - 10/2014
2alpha-Thalassemia
06/2015 - 08/2010
2Genetic Translocation (Chromosomal Translocation)
01/2013 - 12/2008
2Carcinoma (Carcinomatosis)
05/2009 - 04/2003
1Ependymoma
10/2021
1Hypersensitivity (Allergy)
01/2021
1Urinary Bladder Neoplasms (Bladder Cancer)
10/2020
1Carcinosarcoma
01/2019
1Neoplasm Metastasis (Metastasis)
01/2019
1Sotos Syndrome
01/2019
1Pain (Aches)
01/2018
1Neuralgia (Stump Neuralgia)
01/2018
1Peripheral Nerve Injuries
01/2018
1Lung Neoplasms (Lung Cancer)
10/2017
1Chordoma
01/2016
1Cocaine-Related Disorders (Cocaine Addiction)
01/2016
1Bone Neoplasms (Bone Cancer)
01/2016
1Memory Disorders (Memory Loss)
10/2015
1Major Depressive Disorder (Major Depressive Disorders)
10/2015
1Brain Stem Neoplasms (Brain Stem Tumor)
12/2014
1Breast Neoplasms (Breast Cancer)
07/2013
1Nervous System Diseases (Neurological Disorders)
01/2013
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
11/2012
1ATR-X syndrome
06/2011
1X-Linked Mental Retardation (Mental Retardation, X Linked)
08/2010
1Bacterial Infections (Bacterial Infection)
01/2009
1Williams Syndrome (Williams-Beuren Syndrome)
01/2009

Drug/Important Bio-Agent (IBA)

29Histones (Histone)IBA
12/2021 - 04/2003
21ChromatinIBA
12/2021 - 02/2002
18Proteins (Proteins, Gene)FDA Link
10/2021 - 01/2008
11Lysine (L-Lysine)FDA Link
01/2021 - 02/2013
5Methionine (L-Methionine)FDA Link
01/2021 - 10/2014
5Transcription Factors (Transcription Factor)IBA
01/2021 - 01/2009
3Pharmaceutical PreparationsIBA
10/2021 - 12/2014
3EnzymesIBA
11/2020 - 01/2019
3MethyltransferasesIBA
01/2016 - 09/2011
2Biological ProductsIBA
10/2020 - 10/2015
2dipinacoline glutamateIBA
01/2019 - 05/2014
2Phosphotransferases (Kinase)IBA
10/2010 - 02/2002
2Adenosine Triphosphate (ATP)IBA
01/2009 - 09/2007
1Metformin (Glucophage)FDA LinkGeneric
10/2021
1Tricarboxylic AcidsIBA
10/2021
1Hypoglycemic Agents (Hypoglycemics)IBA
10/2021
1RNA (Ribonucleic Acid)IBA
10/2021
1Nucleosomes (Nucleosome)IBA
01/2021
1DNA (Deoxyribonucleic Acid)IBA
01/2021
1Protein Isoforms (Isoforms)IBA
01/2021
1Histone Deacetylase InhibitorsIBA
01/2021
1Glycine (Aminoacetic Acid)FDA LinkGeneric
11/2020
1Histone DemethylasesIBA
10/2020
1Phenobarbital (Luminal)FDA Link
10/2020
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2020
1AsparagineIBA
01/2020
1Amino AcidsFDA Link
01/2020
1Asparaginase (Elspar)FDA Link
01/2020
1LigandsIBA
01/2019
1CholesterolIBA
01/2019
1Liver X ReceptorsIBA
01/2019
1Intergenic DNA (Junk DNA)IBA
01/2019
124,25-epoxycholesterolIBA
01/2019
1Estrogen Receptor alphaIBA
01/2019
1lanosterol synthaseIBA
01/2019
1Aminobutyrates (Aminobutyric Acid)IBA
01/2018
1Glutamic Acid (Glutamate)FDA Link
01/2018
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2018
1gamma-Aminobutyric Acid (GABA)IBA
01/2018
1Serine (L-Serine)FDA Link
10/2017
1AcetyltransferasesIBA
10/2017
1Cocaine (Cocaine HCl)IBA
01/2016
1histone H3 trimethyl Lys4IBA
07/2015
1DNA Transposable Elements (Element, IS)IBA
06/2015
1Sucrose (Saccharose)IBA
06/2015
1Histone MethyltransferasesIBA
10/2014
1Polycomb Repressive Complex 2IBA
02/2013
1Biomarkers (Surrogate Marker)IBA
11/2012
1Oncogene Proteins (Oncogene Protein)IBA
11/2012
1CytosineIBA
11/2012
1Positive Transcriptional Elongation Factor BIBA
09/2011
1HeterochromatinIBA
06/2011
1tyrosine receptor (receptor, tyrosine)IBA
10/2010
1Histone Acetyltransferases (Histone Acetyltransferase)IBA
05/2009
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
12/2008
1Arginine (L-Arginine)FDA Link
03/2008

Therapy/Procedure

5Therapeutics
10/2020 - 11/2012
1Drug Therapy (Chemotherapy)
01/2016